Substitution of DAO
DAO enzyme supplementation for better histamine breakdown in histamine intolerance.
DAO (diamine oxidase) substitution is a method used in people with histamine intolerance. The goal is to supplement the insufficient activity of the DAO enzyme, which is responsible for the breakdown of histamine received from food. In this way, they try to alleviate the symptoms of intolerance.
Related terms
The main enzyme responsible for breaking down histamine in the body. Its deficiency is related to HIT.
An enzyme that breaks down biogenic amines, such as tyramine or serotonin. It also completes the degradation of histamine after it has been processed by HNMT.
The second major enzyme responsible for breaking down histamine. Unlike DAO, it works inside cells within the brain, lungs, skin, and liver. It cannot be supplemented in capsule form.
Substances that reduce the activity of the DAO enzyme, which worsens the breakdown of histamine.
Substances that the DAO enzyme needs to do its job, mainly copper and vitamin B6. Without them, the enzyme cannot work at full capacity, even if there is enough of it in the body.