Cumulative effect
A build-up of histamine in the body from various sources that exceeds tolerance and triggers symptoms.
The cumulative effect describes a situation where histamine from various sources (food, own production, impaired degradation) gradually accumulates in the body. If the total amount of histamine exceeds the individual tolerance limit, the symptoms of histamine intolerance will appear. It is the sum of all factors that increase the level of histamine or decrease its breakdown.
Related terms
The process by which microorganisms convert substances. It is key in HIT because it increases the histamine content of food.
The inability of the body to properly break down histamine, which leads to its excessive accumulation and manifestations.
Substances that release histamine from cells, worsening the symptoms of HIT.
An independent non-profit organization (Schweizerische Interessengemeinschaft Histamin-Intoleranz) that specializes in research, education and support for people suffering from histamine intolerance (HIT) and related disorders of mast cell metabolism.
Immune system cells that release histamine and other mediators in response to HIT triggers.