Swiss Interest Group Histamine Intolerance (SIGHI)
An independent non-profit organization (Schweizerische Interessengemeinschaft Histamin-Intoleranz) that specializes in research, education and support for people suffering from histamine intolerance (HIT) and related disorders of mast cell metabolism.
Key activities and importance:
- Scientific contribution: The organization is internationally recognized mainly thanks to the development of the so-called SIGHI list (comprehensive food database), which categorizes foods according to the content of histamine and other biogenic amines.
- Methodology: Introduces a standardized rating system (0-3) for food tolerance, which serves as a basic guide for elimination diets worldwide.
- Information service: Provides expert information on diagnosis, symptoms and treatment options (e.g. DAO enzyme supplementation) for the lay and professional public.
- Support: Brings together patients, doctors and nutritionists to improve the quality of life of people with chronic histamine problems.
Related terms
The inability of the body to properly break down histamine, which leads to its excessive accumulation and manifestations.
The amount of histamine the body can still break down without issues. It is not fixed and changes from day to day depending on health, medications, hormones, and stress.
Substances that release histamine from cells, worsening the symptoms of HIT.
A build-up of histamine in the body from various sources that exceeds tolerance and triggers symptoms.
The moment a mast cell empties its storage vesicles and releases histamine and other inflammatory substances into its surroundings. This can be triggered by an allergen, but also by medication, heat, or stress.