Swiss Interest Group Histamine Intolerance (SIGHI)
An independent non-profit organization (Schweizerische Interessengemeinschaft Histamin-Intoleranz) that specializes in research, education and support for people suffering from histamine intolerance (HIT) and related disorders of mast cell metabolism.
Key activities and importance:
- Scientific contribution: The organization is internationally recognized mainly thanks to the development of the so-called SIGHI list (comprehensive food database), which categorizes foods according to the content of histamine and other biogenic amines.
- Methodology: Introduces a standardized rating system (0-3) for food tolerance, which serves as a basic guide for elimination diets worldwide.
- Information service: Provides expert information on diagnosis, symptoms and treatment options (e.g. DAO enzyme supplementation) for the lay and professional public.
- Support: Brings together patients, doctors and nutritionists to improve the quality of life of people with chronic histamine problems.
Related terms
The process by which microorganisms convert substances. It is key in HIT because it increases the histamine content of food.
The inability of the body to properly break down histamine, which leads to its excessive accumulation and manifestations.
Substances that release histamine from cells, worsening the symptoms of HIT.
A build-up of histamine in the body from various sources that exceeds tolerance and triggers symptoms.
Immune system cells that release histamine and other mediators in response to HIT triggers.